I remember that with e.g Jak and Daxter: The Precursor Legacy, I've to enable mode 2,3,6, so at lest 3 should work. Try to add your reports with tested\tried compatibility modes & with MD5 checksum. I've tried Capcom Classics Collection Vol. 1 (SLES_536.61) PAL version with OPL 1180 through USB, MD5 checksum = 970bd430d7d3e262f8add3653f891152. I didn't need to enable any compatibility mode(s). For Ratchet and Clank v2.00 (SCES_509.16) PAL version with OPL 1180 through USB, MD5 checksum = 32b8347b2bb80cd30d30ba0601ebb0ee, I also didn't need to enable any compatibility modes. Game starts fine after selecting new game. With Ratchet and Clank 2 (SCES_516.07) PAL version with OPL 1180 through USB, MD5 checksum = e184fc2a495a4654f748a8e8c587261c. Game is booting without any problems. So... In my setup everything runs fine. There can be some differences between PAL and NTSC version, but... could you try another USB HDD?